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S-sulfhydration of MEK1 leads to PARP-1 activation and DNA damage repair
The repair of DNA damage is fundamental to normal cell development and replication. Hydrogen sulfide (H(2)S) is a novel gasotransmitter that has been reported to protect cellular aging. Here, we show that H(2)S attenuates DNA damage in human endothelial cells and fibroblasts by S-sulfhydrating MEK1...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BlackWell Publishing Ltd
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4196983/ https://ncbi.nlm.nih.gov/pubmed/24778456 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/embr.201338213 |
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