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The KCl-cotransporter KCC2 linked to epilepsy
In the mature brain, the neurotransmitter GABA can cause a postsynaptic hyperpolarization via activation of chloride permeant GABA(A) receptor channels. This hyperpolarizing response critically depends on chloride extrusion via the KCl-cotransporter KCC2 1. Its knockdown in mice impairs synaptic inh...
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
BlackWell Publishing Ltd
2014
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| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4196972/ https://ncbi.nlm.nih.gov/pubmed/24928907 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201439039 |
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