Covariance of Charged Amino Acids at Positions 322 and 440 of HIV-1 Env Contributes to Coreceptor Specificity of Subtype B Viruses, and Can Be Used to Improve the Performance of V3 Sequence-Based Coreceptor Usage Prediction Algorithms

The ability to determine coreceptor usage of patient-derived human immunodeficiency virus type 1 (HIV-1) strains is clinically important, particularly for the administration of the CCR5 antagonist maraviroc. The envelope glycoprotein (Env) determinants of coreceptor specificity lie primarily within...

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Hlavní autoři: Cashin, Kieran, Sterjovski, Jasminka, Harvey, Katherine L., Ramsland, Paul A., Churchill, Melissa J., Gorry, Paul R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2014
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4196930/
https://ncbi.nlm.nih.gov/pubmed/25313689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0109771
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