Increased Sensitivity to Broadly Neutralizing Antibodies of End-Stage Disease R5 HIV-1 Correlates with Evolution in Env Glycosylation and Charge

BACKGROUND: Induction of broadly neutralizing antibodies, such as the monoclonal antibodies IgGb12, 2F5 and 2G12, is the objective of most antibody-based HIV-1 vaccine undertakings. However, despite the relative conserved nature of epitopes targeted by these antibodies, mechanisms underlying the sen...

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Hlavní autoři: Borggren, Marie, Repits, Johanna, Sterjovski, Jasminka, Uchtenhagen, Hannes, Churchill, Melissa J., Karlsson, Anders, Albert, Jan, Achour, Adnane, Gorry, Paul R., Fenyö, Eva Maria, Jansson, Marianne
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2011
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3116816/
https://ncbi.nlm.nih.gov/pubmed/21698221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0020135
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