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Loss of γ-cytoplasmic actin triggers myofibroblast transition of human epithelial cells

Transdifferentiation of epithelial cells into mesenchymal cells and myofibroblasts plays an important role in tumor progression and tissue fibrosis. Such epithelial plasticity is accompanied by dramatic reorganizations of the actin cytoskeleton, although mechanisms underlying cytoskeletal effects on...

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Detalhes bibliográficos
Main Authors: Lechuga, Susana, Baranwal, Somesh, Li, Chao, Naydenov, Nayden G., Kuemmerle, John F., Dugina, Vera, Chaponnier, Christine, Ivanov, Andrei I.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4196865/
https://ncbi.nlm.nih.gov/pubmed/25143399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E14-03-0815
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