The Chromatin Assembly Factor 1 Promotes Rad51-Dependent Template Switches at Replication Forks by Counteracting D-Loop Disassembly by the RecQ-Type Helicase Rqh1

At blocked replication forks, homologous recombination mediates the nascent strands to switch template in order to ensure replication restart, but faulty template switches underlie genome rearrangements in cancer cells and genomic disorders. Recombination occurs within DNA packaged into chromatin th...

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Autors principals: Pietrobon, Violena, Fréon, Karine, Hardy, Julien, Costes, Audrey, Iraqui, Ismail, Ochsenbein, Françoise, Lambert, Sarah A.E.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4196752/
https://ncbi.nlm.nih.gov/pubmed/25313826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1001968
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