Development of an enzyme-linked immunosorbent assay for detection of cellular and in vivo LRRK2 S935 phosphorylation

After the discovery of kinase activating mutations in leucine-rich repeat kinase 2 (LRRK2) as associated with autosomal dominant forms of Parkinson’s disease, inhibition of the kinase is being extensively explored as a disease modifying strategy. As signaling properties and substrate(s) of LRRK2 are...

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Bibliografiske detaljer
Main Authors: Delbroek, Lore, Van Kolen, Kristof, Steegmans, Liesbeth, da Cunha, Raquel, Mandemakers, Wim, Daneels, Guy, De Bock, Pieter-Jan, Zhang, Jinwei, Gevaert, Kris, De Strooper, Bart, Alessi, Dario R., Verstreken, Patrik, Moechars, Diederik W.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4196644/
https://ncbi.nlm.nih.gov/pubmed/23313773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpba.2012.12.002
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