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Saccharomyces cerevisiae Sen1 as a Model for the Study of Mutations in Human Senataxin That Elicit Cerebellar Ataxia

The nuclear RNA and DNA helicase Sen1 is essential in the yeast Saccharomyces cerevisiae and is required for efficient termination of RNA polymerase II transcription of many short noncoding RNA genes. However, the mechanism of Sen1 function is not understood. We created a plasmid-based genetic syste...

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Detalhes bibliográficos
Main Authors: Chen, Xin, Müller, Ulrika, Sundling, Kaitlin E., Brow, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: Genetics Society of America 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4196614/
https://ncbi.nlm.nih.gov/pubmed/25116135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.114.167585
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