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Viewing Protein Fitness Landscapes Through a Next-Gen Lens
High-throughput sequencing has enabled many powerful approaches in biological research. Here, we review sequencing approaches to measure frequency changes within engineered mutational libraries subject to selection. These analyses can provide direct estimates of biochemical and fitness effects for a...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Genetics Society of America
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4196605/ https://ncbi.nlm.nih.gov/pubmed/25316787 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.114.168351 |
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