Uncoupling conformational change from GTP hydrolysis in a heterotrimeric G protein α-subunit

Heterotrimeric G protein α (Gα) subunits possess intrinsic GTPase activity that leads to functional deactivation with a rate constant of ≈2 min(-1) at 30°C. GTP hydrolysis causes conformational changes in three regions of Gα, including Switch I and Switch II. Mutation of G202→A in Switch II of Gα(i1...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Thomas, Celestine J., Du, Xinlin, Li, PiLong, Wang, Ying, Ross, Elliott M., Sprang, Stephen R.
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 2004
Sujets:	Biological Sciences
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC419645/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15128951/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0304091101
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