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Uncoupling conformational change from GTP hydrolysis in a heterotrimeric G protein α-subunit
Heterotrimeric G protein α (Gα) subunits possess intrinsic GTPase activity that leads to functional deactivation with a rate constant of ≈2 min(-1) at 30°C. GTP hydrolysis causes conformational changes in three regions of Gα, including Switch I and Switch II. Mutation of G202→A in Switch II of Gα(i1...
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| Autores principales: | , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
2004
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC419645/ https://ncbi.nlm.nih.gov/pubmed/15128951 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0304091101 |
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