Metallothionein protects against the cytotoxic and DNA-damaging effects of nitric oxide.

In inflammatory states, nitric oxide (.NO) may be synthesized from precursor L-arginine via inducible .NO synthase (iNOS) in large amounts for prolonged periods of time. When .NO acts as an effector molecule under these conditions, it may be toxic to cells by inhibition of iron-containing enzymes or...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Schwarz, M A, Lazo, J S, Yalowich, J C, Allen, W P, Whitmore, M, Bergonia, H A, Tzeng, E, Billiar, T R, Robbins, P D, Lancaster, J R
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41962/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7538671/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.10.4452
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