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Single Cell Gel Electrophoresis (SCGE) and Pig-a mutation assay in vivo - tools for genotoxicity testing from a regulatory perspective: a study of benzo[a]pyrene in Ogg1(−/−) mice
The OECD has developed test guidelines (TG) to identify agents with genotoxic effects. The in vivo alkaline single cell gel electrophoresis (SCGE) assay is currently being prepared to become such a TG. The performance of a combined SCGE/Pig-a gene mutation study was evaluated with the prototypical g...
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| Autores principales: | , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4196198/ https://ncbi.nlm.nih.gov/pubmed/25308545 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mrgentox.2014.07.010 |
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