AZD1480 delays tumor growth in a melanoma model while enhancing the suppressive activity of myeloid-derived suppressor cells

AZD1480 is a potent, competitive small-molecule inhibitor of JAK1/2 kinase which inhibits STAT3 phosphorylation and tumor growth. Here we investigated the effects of AZD1480 on the function of different immune cell populations in a melanoma model. When MO4 tumor-bearing mice were treated with AZD148...

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Bibliografske podrobnosti
Main Authors: Maenhout, Sarah K., Four, Stephanie Du, Corthals, Jurgen, Neyns, Bart, Thielemans, Kris, Aerts, Joeri L.
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2014
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4196164/
https://ncbi.nlm.nih.gov/pubmed/25149535
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