Differential effects of metformin on breast cancer proliferation according to markers of insulin resistance and tumor subtype in a randomized presurgical trial

Treatment of diabetics with metformin is associated with decreased breast cancer risk in observational studies, but it remains unclear if this drug has clinical antineoplastic activity. In a recent presurgical trial, we found a heterogeneous effect of metformin on breast cancer proliferation (ki-67)...

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Autores principales: DeCensi, Andrea, Puntoni, Matteo, Gandini, Sara, Guerrieri-Gonzaga, Aliana, Johansson, Harriet Ann, Cazzaniga, Massimiliano, Pruneri, Giancarlo, Serrano, Davide, Schwab, Matthias, Hofmann, Ute, Mora, Serena, Aristarco, Valentina, Macis, Debora, Bassi, Fabio, Luini, Alberto, Lazzeroni, Matteo, Bonanni, Bernardo, Pollak, Michael N.
Formato: Artigo
Lenguaje:Inglês
Publicado: Springer US 2014
Materias:
Clinical Trial
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4196136/
https://ncbi.nlm.nih.gov/pubmed/25253174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10549-014-3141-1
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