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The Warburg effect in tumor progression: Mitochondrial oxidative metabolism as an anti-metastasis mechanism
Compared to normal cells, cancer cells strongly upregulate glucose uptake and glycolysis to give rise to increased yield of intermediate glycolytic metabolites and the end product pyruvate. Moreover, glycolysis is uncoupled from the mitochondrial tricarboxylic acid (TCA) cycle and oxidative phosphor...
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| Main Authors: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2014
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4195816/ https://ncbi.nlm.nih.gov/pubmed/24732809 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2014.04.001 |
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