Genome-wide siRNA screen reveals coupling between mitotic apoptosis and adaptation

The antimitotic anti-cancer drugs, including taxol, perturb spindle dynamics, and induce prolonged, spindle checkpoint-dependent mitotic arrest in cancer cells. These cells then either undergo apoptosis triggered by the intrinsic mitochondrial pathway or exit mitosis without proper cell division in...

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Main Authors: Díaz-Martínez, Laura A, Karamysheva, Zemfira N, Warrington, Ross, Li, Bing, Wei, Shuguang, Xie, Xian-Jin, Roth, Michael G, Yu, Hongtao
Format: Artigo
Jezik:Inglês
Izdano: BlackWell Publishing Ltd 2014
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Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4195789/
https://ncbi.nlm.nih.gov/pubmed/25024437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201487826
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