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Norepinephrine-deficient mice lack responses to antidepressant drugs, including selective serotonin reuptake inhibitors

Mice unable to synthesize norepinephrine (NE) and epinephrine due to targeted disruption of the dopamine β-hydroxylase gene, Dbh, were used to critically test roles for NE in mediating acute behavioral changes elicited by different classes of antidepressants. To this end, we used the tail suspension...

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Uloženo v:
Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Cryan, John F., O'Leary, Olivia F., Jin, Sung-Ha, Friedland, Julie C., Ouyang, Ming, Hirsch, Bradford R., Page, Michelle E., Dalvi, Ashutosh, Thomas, Steven A., Lucki, Irwin
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2004
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC419578/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15148402/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0401080101
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