Norepinephrine-deficient mice lack responses to antidepressant drugs, including selective serotonin reuptake inhibitors

Mice unable to synthesize norepinephrine (NE) and epinephrine due to targeted disruption of the dopamine β-hydroxylase gene, Dbh, were used to critically test roles for NE in mediating acute behavioral changes elicited by different classes of antidepressants. To this end, we used the tail suspension...

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Autori principali: Cryan, John F., O'Leary, Olivia F., Jin, Sung-Ha, Friedland, Julie C., Ouyang, Ming, Hirsch, Bradford R., Page, Michelle E., Dalvi, Ashutosh, Thomas, Steven A., Lucki, Irwin
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2004
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC419578/
https://ncbi.nlm.nih.gov/pubmed/15148402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0401080101
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