Inflammation and MiR-21 Pathways Functionally Interact to Downregulate PDCD4 in Colorectal Cancer

Inflammation plays a direct role in colorectal cancer (CRC) progression; however the molecular mechanisms responsible for this effect are unclear. The inflammation induced cyclooxygenase 2 (COX-2) enzyme required for the production of Prostaglandin E2 (PGE(2)), can promote colorectal cancer by decre...

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Main Authors: Peacock, Oliver, Lee, Andrew C., Cameron, Fraser, Tarbox, Rebecca, Vafadar-Isfahani, Natasha, Tufarelli, Cristina, Lund, Jonathan N.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4195713/
https://ncbi.nlm.nih.gov/pubmed/25310697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0110267
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