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Dramatic acceleration of protein folding by stabilization of a nonnative backbone conformation
Through a mutagenic investigation of Gly-48, a highly conserved position in the Src homology 3 domain, we have discovered a series of amino acid substitutions that are highly destabilizing, yet dramatically accelerate protein folding, some up to 10-fold compared with the wild-type rate. The unique f...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC419538/ https://ncbi.nlm.nih.gov/pubmed/15148398 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0400550101 |
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