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The osmolyte trimethylamine-N-oxide stabilizes the Fyn SH3 domain without altering the structure of its folding transition state
Trimethylamine-N-oxide (TMAO) is a naturally occurring osmolyte that stabilizes proteins against denaturation. Although the impact of TMAO on the folding thermodynamics of many proteins has been well characterized, far fewer studies have investigated its effects on protein folding kinetics. In parti...
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Main Authors: | , , |
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Formato: | Artigo |
Idioma: | Inglês |
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Wiley Subscription Services, Inc., A Wiley Company
2009
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2760359/ https://ncbi.nlm.nih.gov/pubmed/19241379 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.52 |
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