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The osmolyte trimethylamine-N-oxide stabilizes the Fyn SH3 domain without altering the structure of its folding transition state

Trimethylamine-N-oxide (TMAO) is a naturally occurring osmolyte that stabilizes proteins against denaturation. Although the impact of TMAO on the folding thermodynamics of many proteins has been well characterized, far fewer studies have investigated its effects on protein folding kinetics. In parti...

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Detalhes bibliográficos
Main Authors: Lin, Sung Lun, Zarrine-Afsar, Arash, Davidson, Alan R
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley Subscription Services, Inc., A Wiley Company 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2760359/
https://ncbi.nlm.nih.gov/pubmed/19241379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.52
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