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Folding Simulations for Proteins with Diverse Topologies Are Accessible in Days with a Physics-Based Force Field and Implicit Solvent

[Image: see text] The millisecond time scale needed for molecular dynamics simulations to approach the quantitative study of protein folding is not yet routine. One approach to extend the simulation time scale is to perform long simulations on specialized and expensive supercomputers such as Anton....

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Autori principali: Nguyen, Hai, Maier, James, Huang, He, Perrone, Victoria, Simmerling, Carlos
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2014
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4195377/
https://ncbi.nlm.nih.gov/pubmed/25255057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja5032776
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