A novel mouse model of depletion of stellate cells clarifies their role in ischemia/reperfusion- and endotoxin-induced acute liver injury

BACKGROUND & AIMS: Hepatic stellate cells (HSCs) that express glial fibrillary acidic protein (GFAP) are located between the sinusoidal endothelial cells and hepatocytes. HSCs are activated during liver injury and cause hepatic fibrosis by producing excessive extracellular matrix. HSCs also prod...

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Detalhes bibliográficos
Main Authors: Stewart, Rachel K., Dangi, Anil, Huang, Chao, Murase, Noriko, Kimura, Shoko, Stolz, Donna B., Wilson, Gregory C., Lentsch, Alex B., Gandhi, Chandrashekhar R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4195246/
https://ncbi.nlm.nih.gov/pubmed/24060854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2013.09.013
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