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The IL-12Rβ2 gene functions as a tumor suppressor in human B cell malignancies
The IL-12Rβ2 gene is expressed in human mature B cell subsets but not in transformed B cell lines. Silencing of this gene may be advantageous to neoplastic B cells. Our objective was to investigate the mechanism(s) and the functional consequence(s) of IL-12Rβ2 gene silencing in primary B cell tumors...
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| Главные авторы: | , , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Clinical Investigation
2004
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC419484/ https://ncbi.nlm.nih.gov/pubmed/15173892 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200420303 |
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