Long-term in vivo expression of the human glucocerebrosidase gene in nonhuman primates after CD34+ hematopoietic cell transduction with cell-free retroviral vector preparations.

Successful gene transfer into stem cells would provide a potentially useful therapeutic modality for treatment of inherited and acquired disorders affecting hematopoietic tissues. Coculture of primate bone marrow cells with retroviral producer cells, autologous stroma, or an engineered stromal cell...

Полное описание

Библиографические подробности

Опубликовано в::	Proc Natl Acad Sci U S A
Главные авторы:	Xu, L C, Karlsson, S, Byrne, E R, Kluepfel-Stahl, S, Kessler, S W, Agricola, B A, Sellers, S, Kirby, M, Dunbar, C E, Brady, R O
Формат:	Artigo
Язык:	Inglês
Опубликовано:	National Academy of Sciences 1995
Предметы:	Research Article
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41946/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7538667/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.10.4372
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