Long-term in vivo expression of the human glucocerebrosidase gene in nonhuman primates after CD34+ hematopoietic cell transduction with cell-free retroviral vector preparations.

Successful gene transfer into stem cells would provide a potentially useful therapeutic modality for treatment of inherited and acquired disorders affecting hematopoietic tissues. Coculture of primate bone marrow cells with retroviral producer cells, autologous stroma, or an engineered stromal cell...

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Autores principales: Xu, L C, Karlsson, S, Byrne, E R, Kluepfel-Stahl, S, Kessler, S W, Agricola, B A, Sellers, S, Kirby, M, Dunbar, C E, Brady, R O
Formato: Artigo
Lenguaje:Inglês
Publicado: 1995
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC41946/
https://ncbi.nlm.nih.gov/pubmed/7538667
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