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Efficient transfer and sustained high expression of the human glucocerebrosidase gene in mice and their functional macrophages following transplantation of bone marrow transduced by a retroviral vector.

A recombinant retroviral vector (MFG-GC) was used to study the efficiency of transduction of the human gene encoding glucocerebrosidase (GC; D-glucosyl-N-acylsphingosine glucohydrolase, EC 3.2.1.45), in mouse hematopoietic stem cells and expression in their progeny. Transfer of the GC gene to CFU-S...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Ohashi, T, Boggs, S, Robbins, P, Bahnson, A, Patrene, K, Wei, F S, Wei, J F, Li, J, Lucht, L, Fei, Y
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1992
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC50544/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1454816/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.23.11332
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