RNAi-mediated silencing of TEL/AML1 reveals a heat-shock protein— and survivin–dependent mechanism for survival

The TEL/AML1 fusion gene results from the most frequent t(12;21)(p13;q22) translocation in childhood acute lymphoblastic leukemia (ALL). Its contribution to transformation is largely unknown, in particular with respect to survival and apoptosis. We therefore silenced TEL/AML1 expression in leukemic...

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Main Authors: Diakos, Christofer, Krapf, Gerd, Gerner, Christopher, Inthal, Andrea, Lemberger, Christof, Ban, Jozef, Dohnal, Alexander M., Panzer-Grümayer, E. Renate
格式: Artigo
語言:Inglês
出版: 2006
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4194423/
https://ncbi.nlm.nih.gov/pubmed/17095626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-04-019612
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