In vivo dual targeting of the oncogenic Ether-à-go-go-1 potassium channel by calcitriol and astemizole results in enhanced antineoplastic effects in breast tumors

BACKGROUND: The oncogenic ether-à-go-go-1 potassium channel (EAG1) activity and expression are necessary for cell cycle progression and tumorigenesis. The active vitamin D metabolite, calcitriol, and astemizole, a promising antineoplastic drug, target EAG1 by inhibiting its expression and blocking i...

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Detalhes bibliográficos
Main Authors: García-Quiroz, Janice, García-Becerra, Rocío, Santos-Martínez, Nancy, Barrera, David, Ordaz-Rosado, David, Avila, Euclides, Halhali, Ali, Villanueva, Octavio, Ibarra-Sánchez, Maŕa J, Esparza-López, José, Gamboa-Domínguez, Armando, Camacho, Javier, Larrea, Fernando, Díaz, Lorenza
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4194404/
https://ncbi.nlm.nih.gov/pubmed/25280486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-14-745
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