Astemizole Synergizes Calcitriol Antiproliferative Activity by Inhibiting CYP24A1 and Upregulating VDR: A Novel Approach for Breast Cancer Therapy

BACKGROUND: Calcitriol antiproliferative effects include inhibition of the oncogenic ether-à-go-go-1 potassium channel (Eag1) expression, which is necessary for cell cycle progression and tumorigenesis. Astemizole, a new promising antineoplastic drug, targets Eag1 by blocking ion currents. Herein, w...

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Detalhes bibliográficos
Main Authors: García-Quiroz, Janice, García-Becerra, Rocío, Barrera, David, Santos, Nancy, Avila, Euclides, Ordaz-Rosado, David, Rivas-Suárez, Mariana, Halhali, Ali, Rodríguez, Pamela, Gamboa-Domínguez, Armando, Medina-Franco, Heriberto, Camacho, Javier, Larrea, Fernando, Díaz, Lorenza
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3440370/
https://ncbi.nlm.nih.gov/pubmed/22984610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0045063
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