Cannabinoid Receptor Type 2 Agonist Attenuates Apoptosis by Activation of Phosphorylated CREB-Bcl-2 Pathway After Subarachnoid Hemorrhage in Rats

Early brain injury (EBI) which comprises of vasogenic edema and apoptotic cell death is an important component of subarachnoid hemorrhage (SAH) pathophysiology. This study evaluated whether Cannabinoid receptor type 2 (CB2R) agonist, JWH133, attenuates EBI after SAH and whether CB2R stimulation redu...

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Bibliographic Details
Main Authors: Fujii, Mutsumi, Sherchan, Prativa, Soejima, Yoshiteru, Hasegawa, Yu, Flores, Jerry, Doycheva, Desislava, Zhang, John H.
Format: Artigo
Language:Inglês
Published: 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4194247/
https://ncbi.nlm.nih.gov/pubmed/25058046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2014.07.005
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