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LRRK2, a puzzling protein: insights into Parkinson’s disease pathogenesis
Leucine-rich repeat kinase 2 (LRRK2) is a large, ubiquitous protein of unknown function. Mutations in the gene encoding LRRK2 have been linked to familial and sporadic Parkinson disease (PD) cases. The LRRK2 protein is a single polypeptide that displays GTPase and kinase activity. Kinase and GTPase...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4194231/ https://ncbi.nlm.nih.gov/pubmed/24907399 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2014.05.025 |
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