A molecular model for the mechanism of acquired tamoxifen resistance in breast cancer

PURPOSE: Estrogen (E(2))-stimulated growth re-emerges after a c-Src inhibitor blocking E(2)-induced apoptosis. A resulting cell line, MCF-7:PF, is selected with features of functional estrogen receptor (ER) and over-expression of insulin-like growth factor-1 receptor beta (IGF-1Rβ). We addressed the...

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Hauptverfasser: Fan, Ping, Agboke, Fadeke A., Cunliffe, Heather E., Ramos, Pilar, Jordan, V. Craig
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4194144/
https://ncbi.nlm.nih.gov/pubmed/25204804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejca.2014.08.011
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