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Rad17, the clamp loader that loads more than clamps
Rad17 is best known as a checkpoint clamp loader in the activation of ATR kinase signaling. A new study in The EMBO Journal suggests that it also plays a role in initial recruitment of the MRN complex to sites of DNA double-strand breaks, thereby promoting early ATM checkpoint responses and homologo...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
BlackWell Publishing Ltd
2014
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4194106/ https://ncbi.nlm.nih.gov/pubmed/24619000 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/embj.201488223 |
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