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Rad17, the clamp loader that loads more than clamps

Rad17 is best known as a checkpoint clamp loader in the activation of ATR kinase signaling. A new study in The EMBO Journal suggests that it also plays a role in initial recruitment of the MRN complex to sites of DNA double-strand breaks, thereby promoting early ATM checkpoint responses and homologo...

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Detalles Bibliográficos
Main Authors: Paull, Tanya T, Lee, Ji-Hoon
Formato: Artigo
Idioma:Inglês
Publicado: BlackWell Publishing Ltd 2014
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4194106/
https://ncbi.nlm.nih.gov/pubmed/24619000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/embj.201488223
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