The p38alpha mitogen-activated protein kinase limits the CNS proinflammatory cytokine response to systemic lipopolysaccharide, potentially through an IL-10 dependent mechanism

BACKGROUND: The p38α mitogen-activated protein kinase (MAPK) is a well-characterized intracellular kinase involved in the overproduction of proinflammatory cytokines from glia. As such, p38α appears to be a promising therapeutic target for neurodegenerative diseases associated with neuroinflammation...

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Bibliographic Details
Main Authors: Bachstetter, Adam D, Xing, Bin, Van Eldik, Linda J
Format: Artigo
Language:Inglês
Published: BioMed Central 2014
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4193976/
https://ncbi.nlm.nih.gov/pubmed/25297465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-014-0175-6
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