A Pepducin Derived from the Third Intracellular Loop of FPR2 Is a Partial Agonist for Direct Activation of This Receptor in Neutrophils But a Full Agonist for Cross-Talk Triggered Reactivation of FPR2

We recently described a novel receptor cross-talk mechanism in neutrophils, unique in that the signals generated by the PAF receptor (PAFR) and the ATP receptor (P2Y(2)R) transfer formyl peptide receptor 1 (FPR1) from a desensitized (non-signaling) state back to an actively signaling state (Forsman...

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Autores principales: Gabl, Michael, Winther, Malene, Skovbakke, Sarah Line, Bylund, Johan, Dahlgren, Claes, Forsman, Huamei
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4193777/
https://ncbi.nlm.nih.gov/pubmed/25303226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0109516
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