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CHK2 kinase expression is down-regulated due to promoter methylation in non-small cell lung cancer
BACKGROUND: CHK2 kinase is a tumor suppressor that plays important role in DNA damage signaling, cell cycle regulation and DNA damage induced apoptosis. CHK2 kinase expression was known to be ubiquitous in mammalian cells. CHK2-/- cells were remarkably resistant to DNA damage induced apoptosis, mimi...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC419366/ https://ncbi.nlm.nih.gov/pubmed/15125777 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-3-14 |
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