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mtDNA germ line variation mediated ROS generates retrograde signaling and induces pro-cancerous metabolic features

mtDNA non-synonymous germ line variation (G10398A; p.A114T) has remained equivocal with least mechanistic understanding in showing an association with cancer. This has necessitated showing in-vitro how an over-expression within mitochondria of either of the variants produces higher intracellular ROS...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Singh, Rajnish Kumar, Srivastava, Archita, Kalaiarasan, Ponnusamy, Manvati, Siddharth, Chopra, Rupali, Bamezai, Rameshwar N. K.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Nature Publishing Group 2014
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4192639/
https://ncbi.nlm.nih.gov/pubmed/25300428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep06571
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