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mtDNA germ line variation mediated ROS generates retrograde signaling and induces pro-cancerous metabolic features
mtDNA non-synonymous germ line variation (G10398A; p.A114T) has remained equivocal with least mechanistic understanding in showing an association with cancer. This has necessitated showing in-vitro how an over-expression within mitochondria of either of the variants produces higher intracellular ROS...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4192639/ https://ncbi.nlm.nih.gov/pubmed/25300428 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep06571 |
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