Variation in germ line mtDNA heteroplasmy is determined prenatally but modified during subsequent transmission

A genetic bottleneck explains the marked changes in mitochondrial DNA (mtDNA) heteroplasmy observed during the transmission of pathogenic mutations, but the precise timing remains controversial, and it is not clear whether selection plays a role. These issues are critically important for the genetic...

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Αποθηκεύτηκε σε:
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Κύριοι συγγραφείς: Freyer, Christoph, Cree, Lynsey M., Mourier, Arnaud, Stewart, James B., Koolmeister, Camilla, Milenkovic, Dusanka, Wai, Timothy, Floros, Vasileios I., Hagström, Erik, Chatzidaki, Emmanouella E., Wiesner, Rudolph J., Samuels, David C, Larsson, Nils-Göran, Chinnery, Patrick F.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2012
Θέματα:
Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3492742/
https://ncbi.nlm.nih.gov/pubmed/23042113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2427
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