Variation in germ line mtDNA heteroplasmy is determined prenatally but modified during subsequent transmission

A genetic bottleneck explains the marked changes in mitochondrial DNA (mtDNA) heteroplasmy observed during the transmission of pathogenic mutations, but the precise timing remains controversial, and it is not clear whether selection plays a role. These issues are critically important for the genetic...

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Main Authors: Freyer, Christoph, Cree, Lynsey M., Mourier, Arnaud, Stewart, James B., Koolmeister, Camilla, Milenkovic, Dusanka, Wai, Timothy, Floros, Vasileios I., Hagström, Erik, Chatzidaki, Emmanouella E., Wiesner, Rudolph J., Samuels, David C, Larsson, Nils-Göran, Chinnery, Patrick F.
Format: Artigo
Jezik:Inglês
Izdano: 2012
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3492742/
https://ncbi.nlm.nih.gov/pubmed/23042113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2427
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