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Silencing Bcl-2 Expression in Epithelial Cancer Cells Using “Smart” Particles
Short interfering RNA (siRNA) targeted against anti-apoptotic Bcl-2 protein proved to knockdown its expression and trigger cancer cell death. We used degradable, pH-sensitive, comb-like [P(EAA-co-BMA)-b-PNASI-g-P(HMA-co-TMAEMA)] polymer to condense anti-Bcl-2 siRNA into “smart” particles, which prov...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4192611/ https://ncbi.nlm.nih.gov/pubmed/25229941 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/jfb5030167 |
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