Nucleoside Triphosphate Diphosphohydrolase-1 Ectonucleotidase Is Required for Normal Vas Deferens Contraction and Male Fertility through Maintaining P2X1 Receptor Function

In this work, we report that Entpd1(−/−) mice, deficient for the ectonucleotidase nucleoside triphosphate diphosphohydrolase-1 (NTPDase1), produce smaller litters (27% reduction) compared with wild-type C57BL6 animals. This deficit is linked to reduced in vivo oocyte fertilization by Entpd1(−/−) mal...

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Autors principals: Kauffenstein, Gilles, Pelletier, Julie, Lavoie, Elise G., Kukulski, Filip, Martín-Satué, Mireia, Dufresne, Sébastien S., Frenette, Jérôme, Ribas Fürstenau, Cristina, Sereda, Michal J., Toutain, Bertrand, Henrion, Daniel, Sullivan, Robert, Vial, Catherine, Sévigny, Jean
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2014
Matèries:
Molecular Bases of Disease
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4192512/
https://ncbi.nlm.nih.gov/pubmed/25160621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.604082
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