The Region Adjacent to the C-end of the Inner Gate in Transient Receptor Potential Melastatin 8 (TRPM8) Channels Plays a Central Role in Allosteric Channel Activation

The ability of transient receptor potential (TRP) channels to sense and respond to environmental and endogenous cues is crucial in animal sensory physiology. The molecular mechanism of channel gating is yet elusive. The TRP box, a conserved region in the N-end of the C terminus domain, has been sign...

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Autores principales: Taberner, Francisco José, López-Córdoba, Ainara, Fernández-Ballester, Gregorio, Korchev, Yuri, Ferrer-Montiel, Antonio
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Molecular Biophysics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4192508/
https://ncbi.nlm.nih.gov/pubmed/25157108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.577478
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