An N-Ethyl-N-Nitrosourea Induced Corticotropin-Releasing Hormone Promoter Mutation Provides a Mouse Model for Endogenous Glucocorticoid Excess

Cushing's syndrome, which is characterized by excessive circulating glucocorticoid concentrations, may be due to ACTH-dependent or -independent causes that include anterior pituitary and adrenal cortical tumors, respectively. ACTH secretion is stimulated by CRH, and we report a mouse model for...

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Main Authors: Bentley, Liz, Esapa, Christopher T., Nesbit, M. Andrew, Head, Rosie A., Evans, Holly, Lath, Darren, Scudamore, Cheryl L., Hough, Tertius A., Podrini, Christine, Hannan, Fadil M., Fraser, William D., Croucher, Peter I., Brown, Matthew A., Brown, Steve D. M., Cox, Roger D., Thakker, Rajesh V.
Formato: Artigo
Idioma:Inglês
Publicado: Endocrine Society 2014
Assuntos:
Glucocorticoids-CRH-ACTH-Adrenal
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4192286/
https://ncbi.nlm.nih.gov/pubmed/24302625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2013-1247
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