Inhibition of JAK/STAT signaling stimulates adult satellite cell function

Diminished regenerative capacity of skeletal muscle occurs during adulthood. We identified a reduction in the intrinsic capacity of murine adult satellite cells to contribute to regeneration and repopulate the niche. Gene expression analysis identified an increase in expression of JAK/STAT signaling...

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Autores principales: Price, Feodor D., von Maltzahn, Julia, Bentzinger, C. Florian, Dumont, Nicolas A., Yin, Hang, Chang, Natasha C., Wilson, David H., Frenette, Jérôme, Rudnicki, Michael A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4191983/
https://ncbi.nlm.nih.gov/pubmed/25194569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3655
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