Loading...

Dysfunction of dendritic cells in aged C57BL/6 mice leads to failure of natural killer cell activation and of tumor eradication

The reciprocal activation of dendritic cells (DCs) and natural killer cells (NKs) plays a key role in both innate and adaptive immunity. The effect of aging on this cross-talk, a critical step in virus disease control and tumor immunology, has not been reported. Splenic DCs and NKs were purified fro...

Full description

Saved in:
Bibliographic Details
Main Authors: Guo, Zhenhong, Tilburgs, Tamara, Wong, Bonnie, Strominger, Jack L.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2014
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4191753/
https://ncbi.nlm.nih.gov/pubmed/25225399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1414780111
Tags: Add Tag
No Tags, Be the first to tag this record!