Structure–Activity Relationship of 3,5-Diaryl-2-aminopyridine ALK2 Inhibitors Reveals Unaltered Binding Affinity for Fibrodysplasia Ossificans Progressiva Causing Mutants

[Image: see text] There are currently no effective therapies for fibrodysplasia ossificans progressiva (FOP), a debilitating and progressive heterotopic ossification disease caused by activating mutations of ACVR1 encoding the BMP type I receptor kinase ALK2. Recently, a subset of these same mutatio...

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Main Authors: Mohedas, Agustin H., Wang, You, Sanvitale, Caroline E., Canning, Peter, Choi, Sungwoon, Xing, Xuechao, Bullock, Alex N., Cuny, Gregory D., Yu, Paul B.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Chemical Society 2014
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4191596/
https://ncbi.nlm.nih.gov/pubmed/25101911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm501177w
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