The transcriptional co-repressor TLE3 suppresses basal signaling on a subset of estrogen receptor α target genes

Chromatin constitutes a repressive barrier to the process of ligand-dependent transcriptional activity of nuclear receptors. Nucleosomes prevent the binding of estrogen receptor α (ERα) in absence of ligand and thus represent an important level of transcriptional regulation. Here, we show that in br...

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Hlavní autoři: Jangal, Maïka, Couture, Jean-Philippe, Bianco, Stéphanie, Magnani, Luca, Mohammed, Hisham, Gévry, Nicolas
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2014
Témata:
Gene regulation, Chromatin and Epigenetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4191390/
https://ncbi.nlm.nih.gov/pubmed/25223786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku791
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