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Papillon-Lefèvre syndrome patient reveals species-dependent requirements for neutrophil defenses
Papillon-Lefèvre syndrome (PLS) results from mutations that inactivate cysteine protease cathepsin C (CTSC), which processes a variety of serine proteases considered essential for antimicrobial defense. Despite serine protease–deficient immune cell populations, PLS patients do not exhibit marked imm...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4191054/ https://ncbi.nlm.nih.gov/pubmed/25244098 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI76009 |
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