Proteinase 3–dependent caspase-3 cleavage modulates neutrophil death and inflammation

Caspase-3–mediated spontaneous death in neutrophils is a prototype of programmed cell death and is critical for modulating physiopathological inflammatory responses; however, the underlying regulatory pathways remain ill defined. Here we determined that in aging neutrophils, the cleavage and activat...

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Detalhes bibliográficos
Main Authors: Loison, Fabien, Zhu, Haiyan, Karatepe, Kutay, Kasorn, Anongnard, Liu, Peng, Ye, Keqiang, Zhou, Jiaxi, Cao, Shannan, Gong, Haiyan, Jenne, Dieter E., Remold-O’Donnell, Eileen, Xu, Yuanfu, Luo, Hongbo R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4191030/
https://ncbi.nlm.nih.gov/pubmed/25180606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI76246
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