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Neutrophil spontaneous death is mediated by down-regulation of autocrine signaling through GPCR, PI3Kγ, ROS, and actin

Neutrophil spontaneous apoptosis plays a crucial role in neutrophil homeostasis and the resolution of inflammation. We previously established Akt deactivation as a key mediator of this tightly regulated cellular death program. Nevertheless, the molecular mechanisms governing the diminished Akt activ...

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Detalhes bibliográficos
Main Authors: Xu, Yuanfu, Loison, Fabien, Luo, Hongbo R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840335/
https://ncbi.nlm.nih.gov/pubmed/20133633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0912717107
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